A tortured man is transformed into a deadly werewolf when the moon becomes full; after the wolf man frees Frankenstein from a block of ice, the two monsters fight each other; an evil scientist escapes from prison and encounters Dracula and other monsters; Dracula and the Wolf Man seek cures for their afflictions; two freight handlers encounter Dracula and other monsters; a doctor struggles to keep himself from turning into a werewolf during the full moon; an heiress discovers that she may be turning into a werewolf and killing people in a nearby park.