The Human Brain Circulation offers an up-to-date synthesis and summary of current knowledge of the cerebrovascular circulation, with emphasis on the study of isolated vessels. The contributors describe the normal vasculature and the many complex changes that occur with age. Where knowledge of human vessels is deficient, research on animal tissues is included. The book is significant because it challenges some of the traditional assumptions, based on animal studies, of the mechanisms that control the human brain vasculature. The contemporary view presented includes the roles of shear stress and intravascular pressure on the arterial circulation. Among the topics discussed are the receptors for vasoactive substances; the molecular aspects of endothelial function in hemostasis; inflammation and thrombosis; the effect of hypertension; the pathophysiology of vasospasm, ischemia, and reperfusion; and the actions of free radicals. Techniques for the in vivo study of cerebrovascular function are also described. The Human Brain Circulation presents a definitive understanding of this important vasculature and clearly defines the future direction for research into human cerebrovascular disease and its treatment.
