analysis, modeling and drug design
Edición de la obra Protein-protein complexes
| Autor | Martin Zacharias |
|---|---|
| Editorial | Imperial College Press, Distributed by World Scientific Pub., World Scientific Publishing Co Pte Ltd |
| Fecha de publicación | 2010 |
| Lugar | London, Hackensack, NJ |
| Idioma | inglés |
| Páginas | 390 |
| ISBN-13 | 9781848163386, 9781848163393 |
| ISBN-10 | 184816338X, 1848163398 |
| OCLC | 619653723 |
| LCCN | 2010484189 |
| Número de Cutter |
Z16p |
Given the immense progress achieved in elucidating protein-protein complex structures and in the field of protein interaction modeling, there is great demand for a book that gives interested researchers/students a comprehensive overview of the field. This book does just that. It focuses on what can be learned about protein-protein interactions from the analysis of protein-protein complex structures and interfaces. What are the driving forces for protein-protein association? How can we extract the mechanism of specific recognition from studying protein-protein interfaces? How can this knowledge be used to predict and design protein-protein interactions (interaction regions and complex structures)? How can we influence protein-protein interactions by mutagenesis and small-molecule drugs or peptide mimetics? The book consists of 13 review chapters, written by experts, on the characterization of protein-protein interfaces, structure determination of protein complexes, theory of protein-protein binding, prediction of interfaces and prediction of protein-protein complex structures. It serves as a bridge between analyzing protein-protein complexes and the prediction and design of interactions. --Book Jacket.