Mitochondrial dysfunction is increasingly being recognized as the basis of a wide variety of human diseases. Providing an authoritative update on our knowledge of mitochondrial medicine, this text draws together world authorities from various fields to discuss general therapeutic strategies and the treatments. Coverage includes a range of specialties, including cardiology, ophthalmology, otology, nephrology, gastroenterology, hematology-oncology, and reproductive medicine. Accessible and user-friendly, the text also presents translational concepts of mitochondrial biogenesis and genetics in vignettes related to specific questions raised by the disease under discussion.