James Loeb (1867-1933), one of the great patrons and philanthropists of his time, left many enduring legacies both to America, where he was born and educated, and to his ancestral Germany, where he spent the second half of his life. Organized in celebration of the sesquicentenary of his birth, the James Loeb Biennial Conferences were convened to commemorate his achievements in four areas: the Loeb Classical Library (2017), collection and connoisseurship (2019), psychology and medicine (2021), and music (2023). The subject of the inaugural conference was the legacy for which Loeb is best known and the only one to which he attached his name-the Loeb Classical Library, and the three series it has inspired: the I Tatti Renaissance Library, the Dumbarton Oaks Medieval Library, and the Murty Classical Library of India. Including discussions by the four General Editors of each Library's unique history, mission, operations, and challenges, the papers collected in The Loeb Classical Library and Its Progeny also take stock of these series in light of more general themes and questions bearing on translations of "classical" texts and their audiences in a variety of societies past, present, and future.