This book leads students to learn about the process of conducting statistical investigations from data collection, to exploring data, to statistical inference, to drawing appropriate conclusions. We focus on genuine research studies, active learning, and effective use of technology. In particular, we use simulation and randomization tests to introduce students to statistical inference, yielding a strong conceptual foundation that bridges students to theory-based inference approaches, which are presented throughout the book. This approach allows students to see the logic and scope of inference in the first chapter and to repeatedly cycle through these ideas, too often lost to introductory statistics students, throughout the course. Our implementation follows the GAISE recommendations endorsed by the American Statistical Association. -- Preface.