physilogy and functional diversity
Edición de la obra Amiloride-sensitive sodium channels
| Autor | Dale J. Benos |
|---|---|
| Editorial | Academic Press |
| Fecha de publicación | 1999 |
| Lugar | San Diego |
| Idioma | inglés |
| Páginas | 384 |
| Formato | [electronic resource] : |
| ISBN-13 | 9780080585185 |
| ISBN-10 | 0080585183 |
| OCLC | 277641284 |
| Serie | Current topics in membranes -- v. 47 |
| Número de Cutter | B473a |
|---|
Sodium reabsorbing epithelia play a major role in whole-body sodium homeostasis. Some examples of sodium regulating tissues include kidney, colon, lung, and sweat ducts. Sodium transport across these membranes is a two-step process: entry through an amiloride-sensitive sodium channel and exit via the ouabain-sensitive sodium/potassium ATPase. The sodium entry channels are the rate-limiting determinant for transport and are regulated by several different hormones. The sodium channels also play a significant role in a number of disease states, like hypertension, edema, drug-induced hyperkalemia,